S100P

Across TCGA pan-cancer cohorts, S100P RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated S100P data layer compared with 1 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher S100P RNA is associated with worse overall survival. In most high-consensus cancer types, elevated S100P expression acts as an unfavorable survival marker, although some lineages such as SCLC and BLCA show a favorable association.

LUAD, SCLC, and BLCA are the cancer types where S100P RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Tertile	II,III,IV	0.578	0.750	<.001	87	view →
SCLC	OS	Tertile	III,IV	0.771	0.312	.002	46	view →
BLCA	OS	Quartile	All	0.731	0.524	<.001	44	view →
ACC	DFS	Quartile	All	0.317	0.779	.006	33	view →
SKCM	OS	Tertile	All	0.659	0.822	<.001	33	view →
PAAD	DFS	Quartile	All	0.212	0.499	<.001	27	view →
ESCA	DFS	Tertile	IV	0.226	0.704	.024	24	view →
MESO	OS	Median	All	0.198	0.366	.008	23	view →
KICH	DFS	Tertile	III,IV	0.271	0.913	.002	23	view →
LAML	DFS	Median	All	0.696	0.427	.003	20	view →
LIHC	OS	Median	All	0.717	0.842	.006	15	view →
UCEC	DFS	Median	II,III,IV	0.852	0.789	.023	10	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

S100P–LUAD (OS)

Open the LUAD breakdown →