S100P

Across TCGA pan-cancer cohorts, S100P RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of S100P’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where S100P RNA is more highly expressed in tumor relative to normal tissue. In most cancer types S100P is over-expressed in tumor, although a few such as KICH show the opposite, repressed pattern.

COAD, LUAD, and BRCA are the cancer types where S100P tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in S100P RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Male	IV	+4.441	<.001	11	view →
LUAD	Female	III,IV	+4.350	<.001	8	view →
BRCA	Female	II,III,IV	+3.675	<.001	6	view →
KICH	All	III,IV	−0.902	.010	5	view →
PAAD	All	All	+6.595	.008	4	view →
LIHC	Female	All	+3.074	<.001	4	view →
CHOL	Male	All	+3.843	.011	2	view →
UCEC	All	All	+1.661	.004	2	view →
ESCA	All	II,III,IV	+1.385	.045	2	view →
READ	All	All	+1.576	.019	1	view →
LUSC	Male	All	+0.875	.048	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

S100P–COAD

Open the COAD breakdown →