S100G

Across TCGA pan-cancer cohorts, S100G RNA is linked to patient survival in 15 of 34 cancer types, making it the most broadly survival-associated S100G data layer compared with 1 for mutation status and 1 for mass-spec protein.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher S100G RNA is associated with worse overall survival. In most high-consensus cancer types, elevated S100G expression acts as an unfavorable survival marker, although some lineages such as BRCA and UCEC show a favorable association.

KIRC, THCA, and ACC are the cancer types where S100G RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	OS	Median	All	0.506	0.709	<.001	60	view →
THCA	DFS	Tertile	IV	0.338	0.714	.006	51	view →
ACC	OS	Tertile	All	0.156	0.703	.012	43	view →
COAD	DFS	Quartile	All	0.341	0.554	.002	38	view →
DLBC	DFS	Tertile	II,III,IV	0.433	0.944	.008	36	view →
STAD	DFS	Tertile	III,IV	0.379	0.607	.006	31	view →
KIRP	DFS	Tertile	All	0.807	0.922	.013	30	view →
PAAD	OS	Median	All	0.466	0.659	.011	24	view →
BRCA	OS	Median	III,IV	0.934	0.875	.014	21	view →
UCEC	DFS	Quartile	II,III,IV	0.906	0.776	.023	14	view →
LUAD	DFS	Median	All	0.838	0.759	.008	11	view →
UCS	OS	Quartile	III,IV	0.228	0.513	.036	10	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 15 lineages.

S100G–KIRC (OS)

Open the KIRC breakdown →