S100B

Across TCGA patient cohorts, S100B mutation is significantly associated with the RNA expression of many other genes, with 94 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible S100B-associated genes across cancer lineages are MIR548H2, MIR1273H, and RN7SL820P. Each is linked with S100B in more than 1 cancer types. Because this analysis shows association rather than direction, both S100B-to-partner and partner-to-S100B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR548H2 grouped by S100B-low versus S100B-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (S100B→partner) and Y-score (partner→S100B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	MIR548H2 →	+0.482	+7.731	<.001	.009	3	2
UCEC	MIR1273H →	+0.178	+3.036	.001	.009	3	1
UCEC	RN7SL820P →	+0.249	+2.982	<.001	.003	3	1
HNSC	MIR378D1 →	+0.461	+7.954	<.001	.008	3	1
HNSC	MIR4490 →	+0.328	+7.954	<.001	.008	3	1
UCEC	ANKRD9 →	+0.597	+3.470	.002	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 94 associations by consensus.

MIR548H2 by S100B expression — BRCA

Explore this box plot interactively →