S100B

Across TCGA pan-cancer cohorts, S100B RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of S100B’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where S100B RNA is repressed in tumor relative to normal tissue. In most cancer types S100B is over-expressed in tumor, although a few such as COAD and KICH show the opposite, repressed pattern.

COAD, KICH, and BLCA are the cancer types where S100B tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in S100B RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Male	All	−2.034	<.001	11	view →
KICH	Male	II,III,IV	−0.933	<.001	10	view →
BLCA	All	All	−1.428	<.001	8	view →
HNSC	Male	II,III,IV	−1.296	<.001	8	view →
THCA	All	All	+1.045	<.001	8	view →
BRCA	All	III,IV	−4.789	<.001	6	view →
STAD	Male	All	−1.589	<.001	4	view →
KIRC	Male	All	+0.752	<.001	4	view →
LUAD	Female	All	+1.067	<.001	3	view →
READ	All	All	−2.611	.001	2	view →
PRAD	All	All	−1.349	<.001	2	view →
UCEC	All	All	−0.705	.034	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

S100B–COAD

Open the COAD breakdown →