Across TCGA pan-cancer cohorts, S100A7A RNA is linked to patient survival in 19 of 34 cancer types, making it the most broadly survival-associated S100A7A data layer compared with 6 for mutation status.
The strongest signal is observed in breast invasive carcinoma (BRCA), where higher S100A7A RNA is associated with worse overall survival. In most high-consensus cancer types, elevated S100A7A expression acts as an unfavorable survival marker, although some lineages such as ESCA and SARC show a favorable association.
BRCA, UCS, and TGCT are the cancer types where S100A7A RNA most reproducibly stratifies survival.
RNA survival associations by lineage
Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.