Across TCGA pan-cancer cohorts, S100A7A mass-spec protein differs between tumor and matched normal tissue in 2 of 18 cancer types tested, making tumor–normal expression one of S100A7A’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where S100A7A mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types S100A7A is over-expressed in tumor.

HNSC and LSCC are the cancer types where S100A7A tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in S100A7A mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	III,IV	+1.481	<.001	11	view →
LSCC	All	III,IV	+1.063	.036	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 2 strongest of 2 lineages.

Exploration

Same gene, other analysis: S100A7A RNA expression & survival · all S100A7A data types