S100A7

Across TCGA pan-cancer cohorts, S100A7 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated S100A7 data layer compared with 24 for mass-spec protein.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher S100A7 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated S100A7 expression acts as an unfavorable survival marker, although some lineages such as LSCC and UCEC show a favorable association.

LSCC, UCEC, and HNSC are the cancer types where S100A7 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	DFS	Median	III,IV	1.000	0.584	.005	18	view →
UCEC	OS	Quartile	All	1.000	0.805	.013	8	view →
HNSC	OS	Median	III,IV	1.000	0.484	.038	4	view →
LUAD	OS	Median	II,III,IV	0.335	1.000	.049	2	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

S100A7–LSCC (DFS)

Open the LSCC breakdown →