S100A1

Across TCGA pan-cancer cohorts, S100A1 RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated S100A1 data layer compared with 1 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in uveal melanoma (UVM), where higher S100A1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated S100A1 expression acts as an unfavorable survival marker, although some lineages such as PAAD and BLCA show a favorable association.

UVM, SCLC, and PAAD are the cancer types where S100A1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	OS	Tertile	II,III,IV	0.342	0.790	<.001	111	view →
SCLC	OS	Quartile	II,III,IV	0.184	0.695	<.001	57	view →
PAAD	OS	Quartile	II,III,IV	0.736	0.439	<.001	35	view →
BLCA	OS	Quartile	II,III,IV	0.761	0.615	.015	29	view →
THCA	OS	Median	III,IV	0.949	0.772	.005	29	view →
COAD	OS	Quartile	All	0.700	0.886	.008	29	view →
UCS	OS	Median	II,III,IV	0.216	0.591	.002	28	view →
UCEC	DFS	Median	All	0.865	0.926	.002	24	view →
LUSC	OS	Median	II,III,IV	0.692	0.353	.005	24	view →
CHOL	DFS	Tertile	All	0.792	0.095	.004	21	view →
LUAD	OS	Quartile	All	0.819	0.531	<.001	21	view →
ACC	OS	Tertile	II,III,IV	0.721	1.000	.001	18	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

S100A1–UVM (OS)

Open the UVM breakdown →