S100A1

Across TCGA pan-cancer cohorts, S100A1 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of S100A1’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where S100A1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types S100A1 is over-expressed in tumor, although a few such as KICH and HNSC show the opposite, repressed pattern.

THCA, KICH, and HNSC are the cancer types where S100A1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in S100A1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Male	III,IV	+2.114	<.001	11	view →
KICH	Female	II,III,IV	−4.710	<.001	8	view →
HNSC	Male	III,IV	−2.787	<.001	8	view →
BRCA	All	III,IV	−1.971	<.001	8	view →
LIHC	All	All	+0.939	<.001	6	view →
STAD	Male	III,IV	−1.593	.003	4	view →
CHOL	All	All	+3.313	<.001	3	view →
BLCA	Male	IV	−1.335	.015	2	view →
PAAD	All	All	−0.935	.042	2	view →
PRAD	All	All	−0.595	.001	2	view →
LUAD	Male	All	−0.518	.017	2	view →
KIRC	Female	IV	+2.618	<.001	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

S100A1–THCA

Open the THCA breakdown →