S100A1

Across TCGA pan-cancer cohorts, S100A1 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated S100A1 data layer compared with 24 for mass-spec protein and 1 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher S100A1 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated S100A1 expression acts as an unfavorable survival marker, although some lineages such as LUAD and PDAC show a favorable association.

LUAD, PDAC, and CCRCC are the cancer types where S100A1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Tertile	II,III,IV	0.780	0.298	<.001	12	view →
PDAC	DFS	Median	II,III,IV	0.879	0.661	.015	5	view →
CCRCC	OS	Median	II,III,IV	1.000	0.499	.025	4	view →
LSCC	DFS	Quartile	II,III,IV	0.752	1.000	.030	3	view →
HNSC	OS	Median	II,III,IV	0.952	1.000	.016	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

S100A1–LUAD (OS)

Open the LUAD breakdown →