S100A1

Across TCGA pan-cancer cohorts, S100A1 mass-spec protein differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of S100A1’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where S100A1 mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types S100A1 is over-expressed in tumor, although a few such as COAD and HNSC show the opposite, repressed pattern.

COAD, HNSC, and PDAC are the cancer types where S100A1 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in S100A1 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	All	−1.398	<.001	11	view →
HNSC	Male	All	−1.860	<.001	8	view →
PDAC	Female	All	−1.666	<.001	8	view →
LSCC	All	All	−0.692	<.001	6	view →
CCRCC	All	All	+0.493	.002	4	view →
LUAD	Male	III,IV	−0.704	.016	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 6 strongest of 6 lineages.

S100A1–COAD

Open the COAD breakdown →