Across TCGA patient cohorts, RYR2 mutation is significantly associated with the RNA expression of many other genes, with 11,071 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RYR2-associated genes across cancer lineages are HSPE1, ADCY4, and NEK2. Each is linked with RYR2 in more than 7 cancer types. Because this analysis shows association rather than direction, both RYR2-to-partner and partner-to-RYR2 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RYR2→partner) and Y-score (partner→RYR2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	HSPE1 →	+0.377	+2.502	.001	.001	3	8
BRCA	ADCY4 →	-0.390	-1.382	.002	.005	3	8
LUAD	NEK2 →	+0.620	+0.817	<.001	<.001	3	8
STAD	SRP9 →	+0.282	+1.137	.001	.007	3	8
LUAD	CKS1B →	+0.442	+0.934	<.001	<.001	3	8
CESC	USHBP1 →	-0.220	-1.806	.006	.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 11,071 associations by consensus.

Exploration

RYR2 survival (RNA) · tumor vs normal (RNA) · all RYR2 data types