Across TCGA patient cohorts, RYR1 RNA expression is significantly associated with the protein abundance of many other proteins, with 17,486 significant associations in total. HNSC shows the largest number of these associations.

The most reproducible RYR1-associated proteins across cancer lineages are RPL5, GNB4, and SNX18. Each is linked with RYR1 in more than 5 cancer types. Because this analysis shows association rather than direction, both RYR1-to-partner and partner-to-RYR1 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (RYR1→partner) and Y-score (partner→RYR1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	RPL5 →	-0.220	-0.438	<.001	<.001	3	6
GBM	GNB4 →	+0.370	+0.999	<.001	<.001	3	6
COAD	SNX18 →	+0.396	+0.145	<.001	<.001	3	5
HNSC	SYNPO2 →	+1.032	+1.600	<.001	<.001	3	5
COAD	KCTD12 →	+0.533	+0.144	<.001	<.001	3	5
PDAC	SLC35B2_S427 →	-0.747	-0.378	.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 17,486 associations by consensus.

Exploration

RYR1 survival (RNA) · tumor vs normal (RNA) · all RYR1 data types