RYK

Across TCGA patient cohorts, RYK mutation is significantly associated with the RNA expression of many other genes, with 254 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RYK-associated genes across cancer lineages are LINC01903, RN7SKP29, and TRPC7. Each is linked with RYK in more than 1 cancer types. Because this analysis shows association rather than direction, both RYK-to-partner and partner-to-RYK results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LINC01903 grouped by RYK-low versus RYK-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RYK→partner) and Y-score (partner→RYK) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	LINC01903 →	+0.037	+3.186	<.001	.009	3	2
SKCM	RN7SKP29 →	+0.114	+3.422	<.001	.006	3	2
SCLC	TRPC7 →	+0.255	+4.039	<.001	.009	3	1
COAD	KRTAP19-5 →	+0.142	+4.225	<.001	.007	3	1
COAD	DAZ1 →	+0.274	+4.225	<.001	.007	3	1
COAD	FABP12 →	+0.139	+3.096	.005	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 254 associations by consensus.

LINC01903 by RYK expression — SKCM

Explore this box plot interactively →