RYK

Across TCGA pan-cancer cohorts, RYK RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of RYK’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where RYK RNA is more highly expressed in tumor relative to normal tissue. In most cancer types RYK is over-expressed in tumor, although a few such as BRCA and KICH show the opposite, repressed pattern.

HNSC, LIHC, and COAD are the cancer types where RYK tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RYK RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	III,IV	+0.805	<.001	9	view →
LIHC	All	II,III,IV	+0.744	<.001	9	view →
COAD	All	All	+0.437	<.001	6	view →
BRCA	Female	All	−0.296	<.001	6	view →
CHOL	Male	All	+2.073	<.001	5	view →
KICH	Female	All	−1.030	<.001	5	view →
LUSC	All	All	+0.777	<.001	5	view →
UCEC	All	All	−0.689	<.001	2	view →
KIRC	Male	II,III,IV	−0.351	.010	2	view →
LUAD	Male	All	+0.294	.016	2	view →
PRAD	All	All	−0.245	.016	2	view →
ESCA	All	All	+0.623	.027	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

RYK–HNSC

Open the HNSC breakdown →