RYK

Across TCGA patient cohorts, RYK mutation is significantly associated with the immune_cell of many other genes, with 2 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RYK-associated genes across cancer lineages are CD8+ Tem and Skeletal muscle. Each is linked with RYK in more than 1 cancer types. Because this analysis shows association rather than direction, both RYK-to-partner and partner-to-RYK results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CD8+ Tem grouped by RYK-low versus RYK-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RYK→partner) and Y-score (partner→RYK) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CD8+ Tem →	+0.003	+4.481	<.001	.047	3	1
SKCM	Skeletal muscle →	+0.052	+2.813	.023	.037	1	1

Each partner links to its Q-omics profile. Showing the 2 strongest of 2 associations by consensus.

CD8+ Tem by RYK expression — UCEC

Explore this box plot interactively →