RYK

Across TCGA cell cohorts, RYK RNA expression is significantly associated with the go_rna of many other GO terms, with 3,959 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible RYK-associated GO terms across cancer lineages are Midbrain dopaminergic neuron differentiation, Positive regulation of cytoplasmic translation, and Cellular response to hydrostatic pressure. Each is linked with RYK in more than 12 cancer types. Because this analysis shows association rather than direction, both RYK-to-partner and partner-to-RYK results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Midbrain dopaminergic neuron differentiation grouped by RYK-low versus RYK-high in STOMACH.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (RYK→partner) and Y-score (partner→RYK) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	Midbrain dopaminergic neuron differentiation →	+0.156	+0.849	.001	<.001	3	13
STOMACH	Positive regulation of cytoplasmic translation →	+0.129	+0.941	.004	.002	3	12
BREAST	Cellular response to hydrostatic pressure →	+0.093	+0.641	.005	.007	2	13
STOMACH	Vesicle tethering to Golgi →	+0.113	+0.833	<.001	.002	3	12
STOMACH	Regulation of early endosome to late endosome transport →	+0.118	+0.812	<.001	<.001	3	11
PANCREAS	Protein desumoylation →	+0.074	+0.622	.005	.005	2	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,959 associations by consensus.

Midbrain dopaminergic neuron differentiation by RYK expression — STOMACH

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