RYK

Across TCGA cell cohorts, RYK mutation is significantly associated with the RNA expression of many other genes, with 4 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible RYK-associated genes across cancer lineages are C3orf85, PRR23B, and MAGEB4. Each is linked with RYK in more than 1 cancer types. Because this analysis shows association rather than direction, both RYK-to-partner and partner-to-RYK results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C3orf85 grouped by RYK-low versus RYK-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RYK→partner) and Y-score (partner→RYK) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	C3orf85 →	+0.044	+4.539	<.001	.007	3	1
STOMACH	PRR23B →	+0.013	+5.285	<.001	.003	3	1
LARGE_INTESTINE	MAGEB4 →	+0.012	+5.415	.009	.004	3	1
BLOOD_Leukemia	MYOCD →	+1.393	+4.108	<.001	.009	1	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

C3orf85 by RYK expression — BLOOD_Leukemia

Explore this box plot interactively →