Across TCGA cell cohorts, RXRA mutation is significantly associated with the RNA expression of many other genes, with 29 significant associations in total. CNS shows the largest number of these associations.

The most reproducible RXRA-associated genes across cancer lineages are C10orf53, MSGN1, and TAFA1. Each is linked with RXRA in more than 1 cancer types. Because this analysis shows association rather than direction, both RXRA-to-partner and partner-to-RXRA results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RXRA→partner) and Y-score (partner→RXRA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	C10orf53 →	+0.075	+5.044	<.001	.001	3	2
LARGE_INTESTINE	MSGN1 →	+0.082	+3.345	<.001	.007	3	1
LARGE_INTESTINE	TAFA1 →	+0.274	+3.688	<.001	.002	3	1
LARGE_INTESTINE	C14orf180 →	+0.177	+4.155	<.001	.003	3	1
LARGE_INTESTINE	NEXMIF →	+0.264	+3.196	<.001	.007	3	1
BLOOD_Leukemia	EPPIN →	+0.006	+4.922	.005	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 29 associations by consensus.

Exploration

RXRA survival (RNA) · tumor vs normal (RNA) · all RXRA data types