RXFP4

Across TCGA patient cohorts, RXFP4 mutation is significantly associated with the total protein of many other genes, with 15 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RXFP4-associated genes across cancer lineages are mTOR_pS2448, Myosin-IIa_pS1943, and Myosin-IIa. Each is linked with RXFP4 in more than 1 cancer types. Because this analysis shows association rather than direction, both RXFP4-to-partner and partner-to-RXFP4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, mTOR_pS2448 grouped by RXFP4-low versus RXFP4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RXFP4→partner) and Y-score (partner→RXFP4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	mTOR_pS2448 →	-0.191	-3.302	.007	.010	3	1
UCEC	Myosin-IIa_pS1943 →	+0.272	+2.472	.006	.011	3	1
UCEC	Myosin-IIa →	+0.271	+2.466	.002	.011	3	1
UCEC	p62 Lck ligand →	+0.466	+3.169	.002	.018	3	1
UCEC	PCNA →	+0.305	+2.459	.003	.020	3	1
UCEC	Rab25 →	-0.452	-2.459	.004	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

mTOR_pS2448 by RXFP4 expression — UCEC

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