RXFP4

Across TCGA cell cohorts, RXFP4 mutation is significantly associated with the drug of many other genes, with 18 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible RXFP4-associated genes across cancer lineages are MK-2206, BI-2536, and PLK_6522. Each is linked with RXFP4 in more than 1 cancer types. Because this analysis shows association rather than direction, both RXFP4-to-partner and partner-to-RXFP4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MK-2206 grouped by RXFP4-low versus RXFP4-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RXFP4→partner) and Y-score (partner→RXFP4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	MK-2206 →	+0.386	+3.428	.033	.002	3	1
BLOOD_Leukemia	BI-2536 →	+0.339	+2.169	.042	.046	3	1
BLOOD_Leukemia	PLK_6522 →	+0.497	+3.321	.036	.006	3	1
BLOOD_Leukemia	SCH772984 →	-0.505	-2.134	.042	.048	3	1
BLOOD_Leukemia	JQ12 →	+0.397	+2.807	.049	.047	3	1
BLOOD_Leukemia	GSK2110183B →	+0.474	+2.655	.006	.044	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

MK-2206 by RXFP4 expression — BLOOD_Leukemia

Explore this box plot interactively →