RXFP2

Across TCGA patient cohorts, RXFP2 mutation is significantly associated with the RNA expression of many other genes, with 4,923 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RXFP2-associated genes across cancer lineages are SUPV3L1, CD1C, and CD1E. Each is linked with RXFP2 in more than 2 cancer types. Because this analysis shows association rather than direction, both RXFP2-to-partner and partner-to-RXFP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SUPV3L1 grouped by RXFP2-low versus RXFP2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RXFP2→partner) and Y-score (partner→RXFP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SUPV3L1 →	+0.281	+1.765	.007	<.001	3	3
UCEC	CD1C →	-0.505	-1.530	.005	.004	3	3
UCEC	CD1E →	-0.496	-3.161	<.001	<.001	3	3
UCEC	TK1 →	+0.551	+2.606	<.001	<.001	3	3
UCEC	PBK →	+0.929	+2.010	<.001	<.001	3	3
UCEC	CENPX →	+0.458	+2.280	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,923 associations by consensus.

SUPV3L1 by RXFP2 expression — UCEC

Explore this box plot interactively →