RXFP2

Across TCGA patient cohorts, RXFP2 mutation is significantly associated with the total protein of many other genes, with 32 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RXFP2-associated genes across cancer lineages are Caspase-7-cleavedD198, NF-kB-p65_pS536, and CDK1. Each is linked with RXFP2 in more than 2 cancer types. Because this analysis shows association rather than direction, both RXFP2-to-partner and partner-to-RXFP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by RXFP2-low versus RXFP2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RXFP2→partner) and Y-score (partner→RXFP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.461	+1.926	.018	.008	3	3
SKCM	NF-kB-p65_pS536 →	-0.359	-2.000	.010	.029	3	2
SKCM	CDK1 →	+0.132	+1.925	.034	.004	3	2
UCEC	JNK_pT183_Y185 →	-0.174	-2.700	.001	.005	3	2
UCEC	Cyclin-B1 →	+0.505	+2.321	.006	.033	3	2
LUSC	eEF2 →	+0.337	+3.179	<.001	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 32 associations by consensus.

Caspase-7-cleavedD198 by RXFP2 expression — UCEC

Explore this box plot interactively →