RXFP2

Across TCGA cell cohorts, RXFP2 RNA expression is significantly associated with the mutation status of many other genes, with 90 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible RXFP2-associated genes across cancer lineages are PTPRD, MN1, and MT-CYB. Each is linked with RXFP2 in more than 1 cancer types. Because this analysis shows association rather than direction, both RXFP2-to-partner and partner-to-RXFP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PTPRD grouped by RXFP2-low versus RXFP2-high in OESOPHAGUS.

RNA expression associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RXFP2→partner) and Y-score (partner→RXFP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	PTPRD →	+2.857	+0.008	.007	.004	3	2
LUNG_NSCLC_LUSC	MN1 →	+4.643	+0.023	.008	<.001	3	2
CNS	MT-CYB →	+2.464	+0.303	.001	.002	3	2
LUNG_SCLC	MED13L →	+4.044	+0.252	.009	<.001	3	2
LUNG_SCLC	OR2T4 →	+4.044	+0.263	.009	<.001	3	2
OVARY	KIF16B →	+4.228	+0.256	.006	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 90 associations by consensus.

PTPRD by RXFP2 expression — OESOPHAGUS

Explore this box plot interactively →