RXFP2

Across TCGA cell cohorts, RXFP2 mutation is significantly associated with the RNA expression of many other genes, with 17 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible RXFP2-associated genes across cancer lineages are MAGEB4, TMEM78, and OR2AP1. Each is linked with RXFP2 in more than 1 cancer types. Because this analysis shows association rather than direction, both RXFP2-to-partner and partner-to-RXFP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MAGEB4 grouped by RXFP2-low versus RXFP2-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RXFP2→partner) and Y-score (partner→RXFP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	MAGEB4 →	+0.008	+4.437	<.001	.004	3	1
SKIN	TMEM78 →	+0.032	+3.793	<.001	.007	3	1
SKIN	OR2AP1 →	+0.010	+4.437	<.001	.004	3	1
LARGE_INTESTINE	TESPA1 →	+0.212	+3.369	.003	.005	3	1
LARGE_INTESTINE	MDGA2 →	+0.105	+2.591	.002	.008	3	1
LARGE_INTESTINE	JAM2 →	+0.583	+3.228	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

MAGEB4 by RXFP2 expression — SKIN

Explore this box plot interactively →