RXFP2

Across TCGA cell cohorts, RXFP2 mutation is significantly associated with the mutation status of many other genes, with 1,724 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible RXFP2-associated genes across cancer lineages are EPS8, DDX60L, and MYH8. Each is linked with RXFP2 in more than 3 cancer types. Because this analysis shows association rather than direction, both RXFP2-to-partner and partner-to-RXFP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EPS8 grouped by RXFP2-low versus RXFP2-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RXFP2→partner) and Y-score (partner→RXFP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	EPS8 →	+3.187	+3.963	.001	.001	1	4
BLOOD_Leukemia	DDX60L →	+3.728	+4.078	<.001	<.001	1	4
BLOOD_Leukemia	MYH8 →	+2.728	+3.375	.003	.003	1	4
LARGE_INTESTINE	ATRNL1 →	+2.409	+2.767	.001	.001	1	4
SKIN	RBL2 →	+4.357	+4.053	.001	.001	1	3
SKIN	TFR2 →	+4.357	+4.053	.001	.001	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,724 associations by consensus.

EPS8 by RXFP2 expression — SKIN

Explore this box plot interactively →