RWDD4

Across TCGA patient cohorts, RWDD4 mutation is significantly associated with the total protein of many other genes, with 5 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RWDD4-associated genes across cancer lineages are JNK2, STAT3_pY705, and Cyclin-E2. Each is linked with RWDD4 in more than 1 cancer types. Because this analysis shows association rather than direction, both RWDD4-to-partner and partner-to-RWDD4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK2 grouped by RWDD4-low versus RWDD4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RWDD4→partner) and Y-score (partner→RWDD4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK2 →	+0.362	+3.169	<.001	.020	3	1
UCEC	STAT3_pY705 →	-0.642	-3.159	<.001	.019	3	1
UCEC	Cyclin-E2 →	+0.192	+2.817	.038	.036	3	1
UCEC	MEK1 →	+0.628	+3.169	.001	.020	1	1
UCEC	SLC1A5 →	-0.631	-2.992	.010	.036	1	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

JNK2 by RWDD4 expression — UCEC

Explore this box plot interactively →