RWDD2A

Across TCGA pan-cancer cohorts, RWDD2A RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of RWDD2A’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where RWDD2A RNA is repressed in tumor relative to normal tissue. In most cancer types RWDD2A is over-expressed in tumor, although a few such as KICH and THCA show the opposite, repressed pattern.

KICH, THCA, and COAD are the cancer types where RWDD2A tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RWDD2A RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Female	II,III,IV	−1.581	<.001	11	view →
THCA	All	IV	−1.092	<.001	11	view →
COAD	Male	II,III,IV	+0.675	<.001	8	view →
LUSC	Male	All	−0.378	<.001	5	view →
KIRC	All	All	+0.237	.001	5	view →
LIHC	All	All	+0.256	.002	4	view →
CHOL	All	All	+1.045	<.001	2	view →
PAAD	All	All	−0.819	.042	2	view →
READ	Male	All	+0.603	.043	2	view →
PRAD	All	All	+0.480	.002	2	view →
HNSC	All	III,IV	+0.393	.008	2	view →
UCEC	All	All	−0.316	.018	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

RWDD2A–KICH

Open the KICH breakdown →