RWDD1

Across TCGA patient cohorts, RWDD1 mutation is significantly associated with the total protein of many other genes, with 6 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RWDD1-associated genes across cancer lineages are S6_pS240_S244, C-Raf, and ETS-1. Each is linked with RWDD1 in more than 1 cancer types. Because this analysis shows association rather than direction, both RWDD1-to-partner and partner-to-RWDD1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, S6_pS240_S244 grouped by RWDD1-low versus RWDD1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RWDD1→partner) and Y-score (partner→RWDD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	S6_pS240_S244 →	+0.481	+3.000	.040	.037	3	1
UCEC	C-Raf →	+0.273	+3.000	<.001	.037	3	1
UCEC	ETS-1 →	-0.363	-3.000	.048	.037	1	1
UCEC	PEA-15_pS116 →	-0.468	-3.000	.020	.037	1	1
UCEC	Rad50 →	-0.393	-3.000	.005	.037	1	1
UCEC	Annexin_VII →	-0.173	-3.000	.031	.037	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

S6_pS240_S244 by RWDD1 expression — UCEC

Explore this box plot interactively →