RWDD1

Across TCGA cell cohorts, RWDD1 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,017 significant associations in total. UPPER_AERODIGESTIVE_TRACT shows the largest number of these associations.

The most reproducible RWDD1-associated GO terms across cancer lineages are Negative regulation of ubiquitin protein ligase activity, Spermine biosynthetic process, and Glutaminyl-tRNAGln biosynthesis via transamidation. Each is linked with RWDD1 in more than 13 cancer types. Because this analysis shows association rather than direction, both RWDD1-to-partner and partner-to-RWDD1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of ubiquitin protein ligase activity grouped by RWDD1-low versus RWDD1-high in KIDNEY.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (RWDD1→partner) and Y-score (partner→RWDD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	Negative regulation of ubiquitin protein ligase activity →	+0.192	+0.808	.006	.002	3	14
UPPER_AERODIGESTIVE_TRACT	Spermine biosynthetic process →	+0.122	+0.596	<.001	<.001	3	12
PANCREAS	Glutaminyl-tRNAGln biosynthesis via transamidation →	+0.109	+1.095	<.001	<.001	3	12
UPPER_AERODIGESTIVE_TRACT	Protein localization to kinetochore →	+0.115	+0.638	<.001	<.001	3	12
UPPER_AERODIGESTIVE_TRACT	Regulation of chromosome separation →	+0.114	+0.622	<.001	<.001	3	12
STOMACH	Cellular response to nitrosative stress →	+0.184	+0.649	<.001	.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,017 associations by consensus.

Negative regulation of ubiquitin protein ligase activity by RWDD1 expression — KIDNEY

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