RUVBL2

Across TCGA pan-cancer cohorts, RUVBL2 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated RUVBL2 data layer compared with 24 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher RUVBL2 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated RUVBL2 expression acts as an unfavorable survival marker, although some lineages such as LUAD and PDAC show a favorable association.

LUAD, COAD, and CCRCC are the cancer types where RUVBL2 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	DFS	Median	II,III,IV	0.732	0.312	.010	19	view →
COAD	DFS	Median	IV	0.493	0.944	.031	6	view →
CCRCC	DFS	Median	All	0.644	0.842	.018	4	view →
LSCC	DFS	Median	II,III,IV	0.451	0.877	.044	1	view →
PDAC	DFS	Quartile	All	0.793	0.714	.023	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

RUVBL2–LUAD (DFS)

Open the LUAD breakdown →