RUVBL2

Across TCGA pan-cancer cohorts, RUVBL2 RNA differs between tumor and matched normal tissue in 17 of 18 cancer types tested, making tumor–normal expression one of RUVBL2’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where RUVBL2 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types RUVBL2 is over-expressed in tumor, although a few such as KICH show the opposite, repressed pattern.

KIRC, COAD, and KIRP are the cancer types where RUVBL2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RUVBL2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	IV	+0.783	<.001	12	view →
COAD	Female	All	+1.596	<.001	11	view →
KIRP	All	IV	+1.225	<.001	11	view →
BLCA	Male	All	+0.864	<.001	11	view →
LIHC	Female	II,III,IV	+1.370	<.001	9	view →
STAD	Male	II,III,IV	+1.021	<.001	9	view →
HNSC	Male	All	+0.766	<.001	8	view →
LUAD	All	III,IV	+0.666	<.001	8	view →
LUSC	All	II,III,IV	+1.017	<.001	7	view →
UCEC	All	III,IV	+1.041	.002	6	view →
BRCA	All	III,IV	+1.013	<.001	6	view →
CHOL	Male	All	+1.781	<.001	5	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 17 lineages.

RUVBL2–KIRC

Open the KIRC breakdown →