RUVBL2

Across TCGA patient cohorts, RUVBL2 protein abundance is significantly associated with the RNA expression of many other genes, with 15,663 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible RUVBL2-associated genes across cancer lineages are RUVBL1, MRPL3, and UMPS. Each is linked with RUVBL2 in more than 9 cancer types. Because this analysis shows association rather than direction, both RUVBL2-to-partner and partner-to-RUVBL2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, RUVBL2 versus RUVBL1 in UCEC, with a Pearson correlation of 0.44.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RUVBL2→partner) and Y-score (partner→RUVBL2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RUVBL1 →	+1.014	+0.355	<.001	<.001	3	10
HNSC	MRPL3 →	+0.773	+0.227	<.001	<.001	3	8
LSCC	UMPS →	+0.729	+0.295	<.001	<.001	3	7
LSCC	QTRT2 →	+0.550	+0.312	<.001	<.001	3	7
LSCC	CCDC58 →	+0.814	+0.311	<.001	<.001	3	7
LSCC	GMPS →	+0.826	+0.227	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 15,663 associations by consensus.

RUVBL2 vs RUVBL1 — UCEC

Explore this scatter interactively →