RUVBL2

Across TCGA cell cohorts, RUVBL2 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,794 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible RUVBL2-associated GO terms across cancer lineages are Telomerase RNA localization to Cajal body, Telomerase RNA localization, and DNA replication initiation. Each is linked with RUVBL2 in more than 16 cancer types. Because this analysis shows association rather than direction, both RUVBL2-to-partner and partner-to-RUVBL2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Telomerase RNA localization to Cajal body grouped by RUVBL2-low versus RUVBL2-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (RUVBL2→partner) and Y-score (partner→RUVBL2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Telomerase RNA localization to Cajal body →	+0.100	+0.867	.002	.004	3	17
BONE	Telomerase RNA localization →	+0.100	+0.867	.002	.004	3	17
PANCREAS	DNA replication initiation →	+0.137	+0.717	<.001	.001	3	17
PANCREAS	Transcription initiation at RNA polymerase I promoter →	+0.129	+0.990	<.001	<.001	3	17
BONE	Metaphase/anaphase transition of mitotic cell cycle →	+0.225	+0.887	.001	.002	3	16
BONE	Metaphase/anaphase transition of cell cycle →	+0.224	+0.887	.001	.002	3	16

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,794 associations by consensus.

Telomerase RNA localization to Cajal body by RUVBL2 expression — BONE

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