RUVBL2

Across TCGA cell cohorts, RUVBL2 mutation is significantly associated with the RNA expression of many other genes, with 13 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible RUVBL2-associated genes across cancer lineages are C1QL2, LGI1, and NKX2-6. Each is linked with RUVBL2 in more than 1 cancer types. Because this analysis shows association rather than direction, both RUVBL2-to-partner and partner-to-RUVBL2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C1QL2 grouped by RUVBL2-low versus RUVBL2-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RUVBL2→partner) and Y-score (partner→RUVBL2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	C1QL2 →	+0.019	+4.922	<.001	.009	3	2
BLOOD_Leukemia	LGI1 →	+0.129	+5.539	<.001	.003	3	1
BLOOD_Leukemia	NKX2-6 →	+0.591	+5.201	<.001	.006	3	1
BLOOD_Leukemia	OR4F15 →	+0.006	+5.201	<.001	.006	3	1
BLOOD_Leukemia	SPPL2C →	+0.012	+4.922	<.001	.009	3	1
BLOOD_Leukemia	IQCF5 →	+0.124	+5.201	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

C1QL2 by RUVBL2 expression — BLOOD_Leukemia

Explore this box plot interactively →