RUVBL1

Across TCGA pan-cancer cohorts, RUVBL1 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated RUVBL1 data layer compared with 28 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher RUVBL1 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated RUVBL1 expression acts as an unfavorable survival marker, although some lineages such as LUAD and LSCC show a favorable association.

LUAD, CCRCC, and PDAC are the cancer types where RUVBL1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	DFS	Tertile	All	0.906	0.529	.004	25	view →
CCRCC	DFS	Quartile	III,IV	0.418	0.851	.002	9	view →
PDAC	DFS	Quartile	III,IV	0.218	0.491	.022	4	view →
LSCC	DFS	Tertile	II,III,IV	0.767	0.485	.034	2	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

RUVBL1–LUAD (DFS)

Open the LUAD breakdown →