RUVBL1

Across TCGA patient cohorts, RUVBL1 mutation is significantly associated with the total protein of many other genes, with 9 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RUVBL1-associated genes across cancer lineages are FOXO3a_pS318_S321, VHL, and Bax. Each is linked with RUVBL1 in more than 1 cancer types. Because this analysis shows association rather than direction, both RUVBL1-to-partner and partner-to-RUVBL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FOXO3a_pS318_S321 grouped by RUVBL1-low versus RUVBL1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RUVBL1→partner) and Y-score (partner→RUVBL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FOXO3a_pS318_S321 →	-0.171	-2.990	.012	.036	3	1
UCEC	VHL →	-1.178	-3.169	.001	.020	3	1
UCEC	Bax →	+0.400	+3.169	.002	.020	3	1
UCEC	Notch1 →	+0.212	+3.169	.006	.020	1	2
UCEC	Caspase-8 →	-0.314	-3.169	.022	.020	2	1
UCEC	Di-Ras3 →	-0.181	-3.169	.026	.020	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

FOXO3a_pS318_S321 by RUVBL1 expression — UCEC

Explore this box plot interactively →