RUSF1

Across TCGA cell cohorts, RUSF1 mutation is significantly associated with the drug of many other genes, with 4 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible RUSF1-associated genes across cancer lineages are CX-5461, TPCA-1, and KRAS (G12C) Inhibitor-12. Each is linked with RUSF1 in more than 1 cancer types. Because this analysis shows association rather than direction, both RUSF1-to-partner and partner-to-RUSF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CX-5461 grouped by RUSF1-low versus RUSF1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RUSF1→partner) and Y-score (partner→RUSF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	CX-5461 →	+0.740	+2.652	.011	.045	3	1
LARGE_INTESTINE	TPCA-1 →	+0.525	+2.786	.027	.037	3	1
LARGE_INTESTINE	KRAS (G12C) Inhibitor-12 →	+0.537	+2.646	.031	.047	1	1
LARGE_INTESTINE	Y-39983 →	+0.592	+2.652	.005	.045	1	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

CX-5461 by RUSF1 expression — LARGE_INTESTINE

Explore this box plot interactively →