RUSC1

Across TCGA pan-cancer cohorts, RUSC1 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated RUSC1 data layer compared with 24 for mass-spec protein and 9 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher RUSC1 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated RUSC1 expression acts as an unfavorable survival marker, although some lineages such as UCEC and HNSC show a favorable association.

LUAD, GBM, and UCEC are the cancer types where RUSC1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Tertile	All	0.592	1.000	.001	21	view →
GBM	OS	Tertile	All	0.262	0.630	.014	9	view →
UCEC	OS	Quartile	II,III,IV	1.000	0.283	.022	4	view →
HNSC	DFS	Quartile	All	1.000	0.903	.042	2	view →
LSCC	DFS	Median	II,III,IV	0.988	0.849	.047	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

RUSC1–LUAD (OS)

Open the LUAD breakdown →