RUSC1

Across TCGA pan-cancer cohorts, RUSC1 RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of RUSC1’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where RUSC1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types RUSC1 is over-expressed in tumor, although a few such as KICH show the opposite, repressed pattern.

LUAD, HNSC, and BLCA are the cancer types where RUSC1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RUSC1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	Female	III,IV	+1.157	<.001	11	view →
HNSC	Male	All	+0.897	<.001	11	view →
BLCA	Female	All	+1.045	<.001	10	view →
LIHC	Female	II,III,IV	+1.769	<.001	9	view →
KIRC	All	All	+0.373	<.001	9	view →
LUSC	Female	All	+1.437	<.001	8	view →
KICH	Female	All	−1.143	<.001	8	view →
BRCA	All	III,IV	+1.462	<.001	6	view →
STAD	Male	II,III,IV	+0.804	<.001	6	view →
CHOL	Male	All	+3.446	<.001	5	view →
PAAD	All	All	+0.855	.015	4	view →
UCEC	All	All	+0.528	.005	4	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

RUSC1–LUAD

Open the LUAD breakdown →