RUSC1

Across TCGA patient cohorts, RUSC1 mutation is significantly associated with the total protein of many other genes, with 53 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RUSC1-associated genes across cancer lineages are eEF2, PCNA, and GSK-3_pS9. Each is linked with RUSC1 in more than 2 cancer types. Because this analysis shows association rather than direction, both RUSC1-to-partner and partner-to-RUSC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by RUSC1-low versus RUSC1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RUSC1→partner) and Y-score (partner→RUSC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.210	+1.700	.049	.040	3	3
UCEC	PCNA →	+0.249	+2.050	<.001	<.001	3	3
STAD	GSK-3_pS9 →	-0.457	-3.000	.018	.036	3	2
STAD	Chk2 →	+0.427	+3.000	.008	.036	3	2
UCEC	ACVRL1 →	-0.099	-1.664	.015	.019	3	2
UCEC	MEK1 →	+0.377	+2.050	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 53 associations by consensus.

eEF2 by RUSC1 expression — UCEC

Explore this box plot interactively →