RUSC1

Across TCGA cell cohorts, RUSC1 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,656 significant associations in total. BREAST shows the largest number of these associations.

The most reproducible RUSC1-associated GO terms across cancer lineages are DNA integrity checkpoint signaling, Chromosome condensation, and Regulation of protein sumoylation. Each is linked with RUSC1 in more than 12 cancer types. Because this analysis shows association rather than direction, both RUSC1-to-partner and partner-to-RUSC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DNA integrity checkpoint signaling grouped by RUSC1-low versus RUSC1-high in PANCREAS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (RUSC1→partner) and Y-score (partner→RUSC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	DNA integrity checkpoint signaling →	+0.088	+0.808	<.001	<.001	3	13
PANCREAS	Chromosome condensation →	+0.169	+0.875	<.001	<.001	3	12
LUNG_SCLC	Regulation of protein sumoylation →	+0.104	+0.858	.001	.001	3	12
PANCREAS	Cell cycle checkpoint signaling →	+0.083	+0.780	<.001	<.001	3	12
PANCREAS	DNA damage checkpoint signaling →	+0.079	+0.849	<.001	<.001	3	12
KIDNEY	Spindle midzone assembly →	+0.230	+0.735	.001	.001	2	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,656 associations by consensus.

DNA integrity checkpoint signaling by RUSC1 expression — PANCREAS

Explore this box plot interactively →