RUSC1

Across TCGA cell cohorts, RUSC1 mutation is significantly associated with the RNA expression of many other genes, with 280 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible RUSC1-associated genes across cancer lineages are SIGLEC8, OR5M11, and OR10R2. Each is linked with RUSC1 in more than 1 cancer types. Because this analysis shows association rather than direction, both RUSC1-to-partner and partner-to-RUSC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SIGLEC8 grouped by RUSC1-low versus RUSC1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RUSC1→partner) and Y-score (partner→RUSC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	SIGLEC8 →	+0.006	+2.345	.002	.007	3	2
LARGE_INTESTINE	OR5M11 →	+0.057	+2.680	.009	.001	3	2
BLOOD_Leukemia	OR10R2 →	+1.639	+3.966	<.001	.001	3	2
PANCREAS	ACSM2A →	+0.022	+5.000	<.001	.006	3	1
LARGE_INTESTINE	HMGXB4 →	+0.524	+3.237	.006	.003	3	1
LARGE_INTESTINE	MAZ →	+0.537	+2.451	.009	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 280 associations by consensus.

SIGLEC8 by RUSC1 expression — LARGE_INTESTINE

Explore this box plot interactively →