RUNX1

Across TCGA patient cohorts, RUNX1 mutation is significantly associated with the RNA expression of many other genes, with 4,968 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RUNX1-associated genes across cancer lineages are RNU4-88P, RNU6-421P, and C12orf57. Each is linked with RUNX1 in more than 2 cancer types. Because this analysis shows association rather than direction, both RUNX1-to-partner and partner-to-RUNX1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU4-88P grouped by RUNX1-low versus RUNX1-high in LAML.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RUNX1→partner) and Y-score (partner→RUNX1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LAML	RNU4-88P →	+0.762	+3.353	.001	.003	3	3
BRCA	RNU6-421P →	+0.136	+3.064	.002	.007	3	3
COAD	C12orf57 →	+0.820	+3.335	.002	.005	3	3
UCEC	CENPU →	+0.792	+2.394	<.001	<.001	3	3
UCEC	SKA1 →	+0.801	+1.928	<.001	<.001	3	3
UCEC	SLC7A4 →	-0.711	-1.627	.002	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,968 associations by consensus.

RNU4-88P by RUNX1 expression — LAML

Explore this box plot interactively →