RUNDC3B

Across TCGA patient cohorts, RUNDC3B mutation is significantly associated with the total protein of many other genes, with 50 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RUNDC3B-associated genes across cancer lineages are ATM, EGFR_pY1068, and mTOR_pS2448. Each is linked with RUNDC3B in more than 2 cancer types. Because this analysis shows association rather than direction, both RUNDC3B-to-partner and partner-to-RUNDC3B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by RUNDC3B-low versus RUNDC3B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RUNDC3B→partner) and Y-score (partner→RUNDC3B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.527	-3.794	<.001	<.001	3	3
UCEC	EGFR_pY1068 →	-0.220	-1.584	.008	.009	3	2
UCEC	mTOR_pS2448 →	-0.116	-1.664	.020	.019	3	2
UCEC	PCNA →	+0.190	+1.678	.008	.021	3	2
UCEC	Annexin-1 →	+0.466	+1.906	.008	.014	3	2
UCEC	Shc_pY317 →	-0.154	-1.584	.002	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 50 associations by consensus.

ATM by RUNDC3B expression — UCEC

Explore this box plot interactively →