RUNDC3B

Across TCGA pan-cancer cohorts, RUNDC3B RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of RUNDC3B’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where RUNDC3B RNA is repressed in tumor relative to normal tissue. In most cancer types RUNDC3B is over-expressed in tumor, although a few such as COAD and KICH show the opposite, repressed pattern.

COAD, KICH, and BLCA are the cancer types where RUNDC3B tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RUNDC3B RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	All	−1.669	<.001	12	view →
KICH	Female	II,III,IV	−1.457	<.001	11	view →
BLCA	Male	IV	−1.437	<.001	10	view →
UCEC	All	All	−1.741	<.001	6	view →
BRCA	All	All	−1.072	<.001	6	view →
KIRC	Male	II,III,IV	+0.566	.003	6	view →
LUSC	All	All	−0.550	<.001	6	view →
READ	Female	All	−1.954	<.001	5	view →
LIHC	Female	II,III,IV	−1.093	<.001	5	view →
HNSC	All	All	−0.177	.026	5	view →
CHOL	All	II,III,IV	−2.245	<.001	4	view →
STAD	All	All	−0.468	<.001	4	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

RUNDC3B–COAD

Open the COAD breakdown →