RUBCNL

Across TCGA patient cohorts, RUBCNL mutation is significantly associated with the total protein of many other genes, with 36 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RUBCNL-associated genes across cancer lineages are STAT3_pY705, ATM, and Caspase-7-cleavedD198. Each is linked with RUBCNL in more than 1 cancer types. Because this analysis shows association rather than direction, both RUBCNL-to-partner and partner-to-RUBCNL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, STAT3_pY705 grouped by RUBCNL-low versus RUBCNL-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RUBCNL→partner) and Y-score (partner→RUBCNL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	STAT3_pY705 →	-0.356	-2.321	<.001	.005	3	2
UCEC	ATM →	-0.652	-3.687	<.001	.001	3	2
UCEC	Caspase-7-cleavedD198 →	+0.815	+2.242	<.001	.005	3	2
UCEC	C-Raf →	+0.152	+2.000	.003	.009	3	2
UCEC	14-3-3_beta →	-0.112	-3.558	.001	.002	3	1
UCEC	eEF2 →	+0.445	+1.925	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 36 associations by consensus.

STAT3_pY705 by RUBCNL expression — UCEC

Explore this box plot interactively →