RUBCNL

Across TCGA cell cohorts, RUBCNL mutation is significantly associated with the RNA expression of many other genes, with 28 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible RUBCNL-associated genes across cancer lineages are C5orf67, PRDM14, and C8orf89. Each is linked with RUBCNL in more than 1 cancer types. Because this analysis shows association rather than direction, both RUBCNL-to-partner and partner-to-RUBCNL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C5orf67 grouped by RUBCNL-low versus RUBCNL-high in LUNG_NSCLC_LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RUBCNL→partner) and Y-score (partner→RUBCNL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	C5orf67 →	+0.108	+4.137	<.001	.001	3	1
OESOPHAGUS	PRDM14 →	+0.006	+4.017	<.001	.007	3	1
OESOPHAGUS	C8orf89 →	+0.182	+4.017	<.001	.007	3	1
LARGE_INTESTINE	MS4A4A →	+0.182	+3.000	<.001	.006	3	1
LARGE_INTESTINE	TAFA1 →	+0.234	+3.103	.002	.004	3	1
LARGE_INTESTINE	KRTAP10-2 →	+0.050	+2.994	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 28 associations by consensus.

C5orf67 by RUBCNL expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →