RUBCN

Across TCGA patient cohorts, RUBCN protein abundance is significantly associated with the RNA expression of many other genes, with 6,373 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible RUBCN-associated genes across cancer lineages are PTPN22, HYKK, and LILRB2. Each is linked with RUBCN in more than 4 cancer types. Because this analysis shows association rather than direction, both RUBCN-to-partner and partner-to-RUBCN results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, RUBCN versus PTPN22 in LUAD, with a Pearson correlation of 0.43.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RUBCN→partner) and Y-score (partner→RUBCN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	PTPN22 →	+0.921	+0.235	<.001	<.001	3	5
OV	HYKK →	-0.608	-0.817	<.001	<.001	3	4
LSCC	LILRB2 →	+0.747	+0.242	.002	<.001	3	4
UCEC	EPSTI1 →	+1.240	+0.687	<.001	<.001	3	4
HNSC	SP110 →	+0.615	+0.224	.005	.004	3	4
UCEC	CD53 →	+1.172	+0.739	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,373 associations by consensus.

RUBCN vs PTPN22 — LUAD

Explore this scatter interactively →